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Table 1 RC Details on significant complexes differentiating normal and cancer phenotypes

From: Quantitative proteomics signature profiling based on network contextualization

CORUM ID Complex name Functionalities qPSP pvalue
298 VEGF transcriptional complex This complex regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. 0.010
1178 BCOR complex (Ubiquitin E3 ligase) Ubiquitin E3 ligases covalently attach ubiquitin to a lysine residue on a target protein. Polyubiquitination marks proteins for degradation by the proteasome. The BCOR complex contains E3 ligase activity for histone H2A. Monoubiquitylated H2A is present together with the BCOR complex at BCL6 target genes in B cells. This strongly suggests a role of BCOR as regulator of BCL6, a sequence-specific transcriptional repressor, that probably plays an important role in lymphomagenesis. 0.010
36 AP1 adaptor complex This adaptor-related complex participates in a transport step different from that of AP-1. It may function at some trafficking step in the complex pathways between the TGN and the cell surface. 0.010
144 Gamma-BAR-AP1 complex Protein targeting and endocytosis 0.012
5380 TRBP containing complex Translation regulation 0.0016
5268 TNF-alpha/NF-kappa B signaling complex 7 Cytokine activity 0.02
1193 Rap1 complex DNA repair; telomere maintenance 0
193 PA700-20S-PA28 complex Proteasomal degradation 0
1332 Large Drosha complex RNA processing 0.0001
5177 Polycystin-1 multiprotein complex Kidney tissue differentiation 0.021
2318 ITGA6-ITGB4-Laminin10/12 complex Cell adhesions 0.0001
191 20S proteasome proteasomal degradation 0
194 PA28gamma-20S proteasome proteasomal degradation 0
5179 NCOA6-DNA-PK-Ku-PARP1 complex DNA repair 0
5266 TNF-alpha/NF-kappa B signaling complex 6 Cyokine activity 0