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Fig. 2 | Biology Direct

Fig. 2

From: Bacterial calpains and the evolution of the calpain (C2) family of peptidases

Fig. 2

Representative domain architectures for calpain homologues. Domain architecture diagrams were downloaded from the Pfam website ( Diagrams are shown in the same order as they occur in Fig. 1, starting with homologues from bacteria and proceeding in a clockwise direction. The UniProt identifier for each protein is shown on the left. In each domain architecture diagram sequence length is indicated by the horizontal grey line (the “string”): sequence lengths are approximately proportional to one another. Domains are shown in the order they appear in the sequence as “beads on a string”. A domain with rounded ends is complete; a domain with a ragged end matches only a fragment of the complete domain as defined in Pfam. All calpain domains are shown in green and labelled “peptidase C2”; other domains are shown in other colours. Small rectangles indicate transmembrane regions (pink), disordered regions (grey), regions of low complexity (pale blue), and regions of coiled-coil (green). Blue “lollipops” at the top edge of a domain indicate active site residues (in the order Cys, His, Asn). Carbohydrate attachment sites are shown as square-topped lollipops at the bottom edge of a domain (where known). Key to sequences (unp = unnamed protein, domains are shown as strings with each domain separated by a tilde, pC2 = calpain domain): E5XTU0_9ACTO, unp (Segniliparus rugosus strain ATCC BAA-974), pC2; E5C759_9BACE, unp (Bacteroides sp. D2), pC2; Q7NDU2_GLOVI, Glr4140 protein (Gloeobacter violaceus strain PCC 7421), HemolysinCabind x 8 ~ pC2 Q8YZT8_NOSS1, Alr0369 protein (Nostoc sp. strain PCC 7120), PPC ~ pC2; K1Q056_CRAGI, calpain-A (Crassostrea gigas (Pacific oyster)), pC2 ~ Calpain III x 2 ~ EF hand 8; K9TN70_9CYAN, unp (Oscillatoria acuminata strain PCC 6304), DUF4114 ~ pC2; N9TPR9_ENTHI, unp (Entamoeba histolytica strain HM-1:IMSS-A), pC2 ~ LIM; ADGB_HUMAN, androglobin (human), pC2; I1CS59_RHIO9, unp (Rhizopus delemar), MIT ~ pC2; R7V270_CAPTE, unp (Capitella teleta), MIT x 2 ~ pC2 ~ Calpain III x 2; G4LXK3_SCHMA, calpain-7 (Schistosoma mansoni), UCH ~ MIT ~ pC2 ~ Calpain III; CAN7_HUMAN, calpain-7 (human), MIT ~ pC2 ~ Calpain III; D2VVS6_NAEGR, unp (Naegleria gruberi), TPR 1 ~ TPR 11 ~ pC2 ~ Calpain III; D2V3V2_NAEGR, unp (Naegleria gruberi), TPR 8 ~ TPR 11 ~ pC2; L1J1Q4_GUITH, unp (Guillardia theta strain CCMP2712), pC2 ~ Calpain III x 3; L1J739_GUITH, unp (Guillardia theta strain CCMP2712), pC2 ~ Calpain III ~ pC2 ~ Calpain III; L1J0U9_GUITH, unp (Guillardia theta strain CCMP2712), pC2 x 2; Q012Z6_OSTTA, CG1391-PB, isoform B (Ostreococcus tauri), UBA 4 ~ zf GRF ~ pC2; C1MTG3_MICPC, unp (Micromonas pusilla strain CCMP1545), UBA 4 ~ zf GRF ~ pC2~; CAN15_HUMAN, calpain-15 (human), zf RANBP x 3 ~ pC2; G4TER7_PIRID, unp (Piriformospora indica strain DSM 11827), pC2 ~ ZZ x 2; D6W573_HUMAN, HCG1988128 isoform CRA_b (human), pC2 ~ Calpain III; CAN13_HUMAN, calpain-13 (human), pC2 ~ Calpain III; K1PHX3_CRAGI, calpain-9 (Crassostrea gigas (Pacific oyster)), Pkinase x 2 ~ pC2 ~ Calpain III; CAN6_HUMAN, calpain-6 (human), pC2 ~ Calpain III ~ C2; CAN5_HUMAN, calpain-5 (human), pC2 ~ Calpain III ~ C2; CAN10_HUMAN, calpain-10 (human), pC2 ~ Calpain III x 2; X1Y3H7_ANODA, unp (Anopheles darlingi), Pkinase Tyr ~ pC2 ~ Calpain III ~ pC2 ~ Calpain III; CAN12_HUMAN, calpain-12 (human), pC2 ~ Calpain III; CAN3_HUMAN, calpain-3 (human), pC2 ~ Calpain III ~ Calpain u2 ~ EF-hand 5; CAN9_HUMAN, calpain-9 (human), pC2 ~ Calpain III; CAN11_HUMAN, calpain-11 (human), pC2 ~ Calpain III; CAN8_HUMAN, calpain-8 (human), pC2 ~ Calpain III; CAN2_HUMAN, calpain-2 (human), pC2 ~ Calpain III ~ EF-hand 8; CAN1_HUMAN, calpain-1 (human), pC2 ~ Calpain III ~ EF-hand 8

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