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Table 2 Cell lines and the defects they harbour for DNA-damage response (DDR) genes

From: Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer

Cell line / Gene A ATM BRCA1 BRCA2 PTEN TP53
HCC1500 MUT; DOWN     
HCC1419 DOWN     MUT
HCC1395 DOWN MUT; DOWN MUT; DOWN MUT
HCC1806      
HCC1143      MUT
HCC38   DOWN   DOWN MUT; HOMDEL
HCC1187 DOWN DOWN    
HCC1954 DOWN     MUT
MCF7 DOWN     
HCC1428 DOWN     HOMDEL
  1. Genome-wide (~16000 genes) essentiality data [31, 32] from ten cancer cell lines that harbour defects (mutations MUT, downregulation DOWN or homologous deletions HOMDEL) in at least one of the DDR genes ATM, BRCA1, BRCA2, PTEN and TP53