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Table 2 Cell lines and the defects they harbour for DNA-damage response (DDR) genes

From: Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer

Cell line / Gene A

ATM

BRCA1

BRCA2

PTEN

TP53

HCC1500

MUT; DOWN

    

HCC1419

DOWN

   

MUT

HCC1395

DOWN

MUT; DOWN

MUT;

DOWN

MUT

HCC1806

     

HCC1143

    

MUT

HCC38

 

DOWN

 

DOWN

MUT; HOMDEL

HCC1187

DOWN

DOWN

   

HCC1954

DOWN

   

MUT

MCF7

DOWN

    

HCC1428

DOWN

   

HOMDEL

  1. Genome-wide (~16000 genes) essentiality data [31, 32] from ten cancer cell lines that harbour defects (mutations MUT, downregulation DOWN or homologous deletions HOMDEL) in at least one of the DDR genes ATM, BRCA1, BRCA2, PTEN and TP53
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Biology Direct

ISSN: 1745-6150

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