TY - JOUR AU - Veitia, Reiner A. AU - Birchler, James A. PY - 2015 DA - 2015/08/15 TI - Models of buffering of dosage imbalances in protein complexes JO - Biology Direct SP - 42 VL - 10 IS - 1 AB - Stoichiometric imbalances in macromolecular complexes can lead to altered function. Such imbalances stem from under- or over-expression of a subunit of a complex consequent to a deletion, duplication or regulatory mutation of an allele encoding the relevant protein. In some cases, the phenotypic perturbations induced by such alterations can be subtle or be lacking because nonlinearities in the process of protein complex assembly can provide some degree of buffering. SN - 1745-6150 UR - https://doi.org/10.1186/s13062-015-0063-8 DO - 10.1186/s13062-015-0063-8 ID - Veitia2015 ER -