The human transmembrane proteome

Biology Direct

Table 4 Topology prediction results on the experimental benchmark set

	HMMTOP^a	Membrain	MEMSAT-SVM	Octopus	Philius	Phobius	Pro	Prodiv	Scampi-Msa	TMHMM	TOPCONS	CCTOP^a	CCTOP
Sens/res	0.92	0.88	0.95	0.92	0.92	0.92	0.9	0.83	0.94	0.88	0.93	0.96	0.96
Spec/res	0.92	0.97	0.92	0.97	0.96	0.94	0.96	0.94	0.91	0.97	0.94	0.96	0.97
MCC/res	0.92	0.92	0.94	0.94	0.94	0.93	0.93	0.83	0.92	0.92	0.91	0.96	0.96
Acc _Tpg /prot	66	67	70	73	72	68	67	57	64	67	64	82	85
Acc _Top /prot	57	0	59	63	68	64	52	44	60	60	59	80	84

Prediction accuracies of the various topology prediction methods on the experimental benchmark set. Sens/res, Spec/res, and MCC/res mean per-residue sensitivity, specificity, and Matthew correlation coefficient, respectively. Acc_Tpg/prot and Acc_Top/prot mean per/-protein topography and topology accuracies multiplied 100, respectively (^apredictions were made without topological constraints)

ISSN: 1745-6150