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Table 1 Results of the various signal peptide prediction methods on the human benchmark set

From: The human transmembrane proteome

  Philius Phobius SignalP SPOctopus
TP 204 196 194 168
FP 24 21 14 22
TN 234 237 244 235
FN 12 20 22 49
Sensitivity 0.94 0.91 0.90 0.77
Specificity 0.91 0.92 0.95 0.91
MCC 0.84 0.83 0.85 0.70
  1. TP: number of true positives; FP: number of false positives; TN: number of true negatives; FN: number of false negatives; specificity is TN/(TN + FP); sensitivity is TP/(TP + FN); MCC: Matthew’s Correlation Coeffitient is (TP*TN-FP*FN)/sqrt ((TP + FP)*(TP + FN)*(TN + FP)*(TN + FN))