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Fig. 4 | Biology Direct

Fig. 4

From: Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks

Fig. 4

Effect of elimination of more than one Betti-derived targets from the Acute Myeloid Leukemia Protein-Protein Interaction network. The AML PPI network was imported into Cytoscape®, and all nodes except for the RAS family and their neighbors, were eliminated for graphical purposes only. As seen in panel a, the RAS family of proteins indicates that each of respective proteins (HRAS, KRAS and NRAS) is equivalent in importance and interconnected with similar neighbors. Panel b shows the effect of inhibition of NRAS and the resulting reduction in complexity

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