From: Genome-scale identification and characterization of moonlighting proteins
Moonlighting proteins | Interacting proteins | |||||
---|---|---|---|---|---|---|
Uniprot ID/Name a) | Primary function b) | Secondary function c) | UniProt ID/Name d) | Interacting protein function e) | MP/non-MP f) | Ref. |
P93834/HXK2 | Glucose metabolism | Glucose signalling | Q42525/HXK1 | 1. Glycolysis | MP, I | |
2. Sugar mediated signaling programmed cell death | ||||||
Q99798/ACO2 | TCA cycle enzyme | Iron homeostasis | P21399/ACO1 | 1. Role in TCA cycle | MP, I | |
mRNA binding and role in iron homeostasis | ||||||
P00924/ENO1 | Galactose catabolism enzyme | Homotypic vacuole fusion | P00925/ENO2 | 1. Glycolysis | MP, I | [89] |
Vacuole fusion | ||||||
Q08438/Vhs3 | Halotorance determinant | Coenzyme A biosynthesis | P36024/SIS2 | 1. CoA biosynthesis | MP, I | [90] |
Salt tolerance | ||||||
P28482/ERK2 | MAP kinase | Transcriptional | P01100 | 1. Regulation of transcription | MP, II | |
 |  | Repressor | /FOS | 2. Activates phospholipid synthesis in growing cells (regulated by Mos/MAP kinase pathway) |  |  |
Q15796/SMAD2-5 | 1. TGF signaling protein | Multi-domain | [93] | |||
2. Tumor suppressor, dual role in transcriptional activation | ||||||
P05771/PRKCB | 1. Serine/threonine-protein kinase, activates transcription. | MP, II | [94] | |||
Inhibition of the insulin gene transcription. | ||||||
O43293 | 1. Serine/threonine kinase | MP, I | ||||
/DAPK3 | 2. Role in apoptosis, transcription, regulation of cell polarity, contractile processes in non-muscle or smooth muscle cells, and cytokinesis | |||||
P14921/ETS1 | Transcription factor | nonMP | - | |||
P19838/NFKB1 | 1. Transcription factor | MP, I | [97] | |||
2. Cytoplasmic retention of attached NF-kappa-B proteins by p105, generation of p50 by a co-translational processing, transcriptional repressor | ||||||
O43318 | 1. MAPK | MP, II | ||||
/MAP3K7 | Regulates TF activator proteins | |||||
Q99ML3/STAT3 | Transcription factor | Electron transport chain | Q5EG47/Prkaa1-2 | 1. Protein kinase that phosphorylates TF | MP, II | [100] |
Regulation of cellular energy | ||||||
Q62120/Jak2-3 | 1. Tyrosine protein kinase | Multi-domain | [101] | |||
Regulation of cellular signaling and cell cycle control | ||||||
P05480/Src | 1. Tyrosine protein kinase | Multi-domain | [102] | |||
Cytokine/cellular receptor | ||||||
O14786/Neuropilin-1 | Vascular endothelial growth factor | Receptor for semaphorin III | Q14563/SEMA3A-G | 1. Development of the olfactory system and in neuronal control of puberty | MP, II | [103] |
2. Ensures proper endothelial abundance of soluble and alternatively spliced form of VEGF receptor(flt1) | ||||||
P15692/VEGFA | Vascular endothelial growth factor | nonMP | - | |||
P17948 | 1. VEGF receptor; plays negative role in angiogenesis in the embryo most likely by trapping VEGF | MP, I | [104] | |||
/FLT1/VEGFR/ | 2. Plays positive role in adulthood in a tyrosine kinase-dependent manner | |||||
P54279/PMS2 | Mismatch repair enzyme | Hypermutation of antibody variable chains | Q9JK91/Mlh1 | 1. Mismatch repair protein | MP, I | [105] |
Somatic hyper mutation | ||||||
P19971/PD-ECGF | Thymidine phosphorylase | Platelet-derived endothelial cell growth factor | P04183/TK1-2 | 1. Phosphotransferase activity | nonMP | - |
Q96B60 | Deoxyribonucleotidase, mitochondrial | nonMP | - | |||
/NT5E, NT5M | ||||||
P06744/Neuroleukin | Phosphoglucose Isomerase | Differentiation, maturation mediator | P52789/HK2 | 1. Hexokinase-2 | MP, III | [106] |
HK2 detachment causes apoptosis | ||||||
P04075/ALDOA-C | 1. Glycolysis and gluconeogenesis | MP, III | ||||
Regulation of cell shape | ||||||
P30613/PKLR | 1. Pyruvate kinase | MP, III | [109] | |||
Mutation causes hemolytic anemia | ||||||
P14618/PKM2 | 1. Pyruvate kinase | MP, III | [110] | |||
Programmed cell death | ||||||
P06795/P-glycoprotein | P-glycoprotein (transporter) | Regulator of cell-swelling ion channel (K+/Cl-) | P41233/Abca1 | Anion transporter | nonMP | - |
Q91XR9/Phospholipid hydroperoxide glutathione peroxidase | Antioxidant of mature sperm | Structural protein of the mitochondrial capsule | Q60928/Ggt1 | 1. Part of the cell antioxidant defense mechanism | MP, IV | |
2. Indirectly regulates multiple aspects of skeletal biology | ||||||
Q9P2J5/Leucine-tRNA ligase | tRNA synthetases | Translocation and activation of mTORC1 to lysosomal membrane | Q9H6Q3/MARS | Methionine-tRNA ligase, cytoplasmic | nonMP | - |
Q6P0M4/IARS | tRNA aminoacylation for protein translation | nonMP | - | |||
P11325/Nam2p | Mitochondrial leucyl-tRNA synthetase | bI4 mitochondrial RNA splicing activity | P26637/CDC60 | Leucine-tRNA ligase, cytoplasmic | nonMP | - |
P19414/ACO1 | TCA cycle enzyme | Mitochondrial DNA stability | P33421/SDH3 | Succinate dehydrogenase involved in mt-electron transport chain | nonMP | - |