Table 2 Multi-domain proteins with multiple functions identified in E. coli
From: Genome-scale identification and characterization of moonlighting proteins
Gene ID /Protein name/uniprot ID | First function | Additional functions | Ref. |
|---|---|---|---|
b0002/P00561/ThrA | Aspartokinase | Homoserine dehydrogenase | [67] |
b0529/P24186/FolD | Oxidation of methylenetetrahydrofolate | Hydrolysis of methenyltetrahydrofolate | [68] |
b1241/P0A9Q7/AdhE | Alcohol dehydrogenase | Acetaldehyde dehydrogenase; Pyruvate-formate-lyase deactivase | |
b1888/P07363/CheA | Chematoxis sensor kinase | Regulation of protein; dephosphorylation | |
b2255/P77398/ArnA | Oxidative decarboxylation of UDP-glucuronic acid | Formyltransferase | [73] |
b3052/P76658/HldE | D-beta-D-heptose 7-phosphate kinase | D-beta-D-heptose 1-phosphate adenosyltransferase | [74] |
b3368/P0AEA8/CysG | SAM-dependent methylation | NAD-dependent ring dehydrogenation; Ferrorochelation | [75] |
b3650/P0AG24/SpoT | ppGpp synthase | ppGpp hydrolase | |
b3940/P00562/MetL | Aspartokinase | Homoserine dehydrogenase | [67] |
b4390/P27278/NadR†| Transcriptional regulator | Nicotinamide mononucleotide adenylyltransferase; Ribosylnicotinamide kinase | [78] |