Figure 5

Interacting proteins of moonlighting and non-moonlighting proteins. Physically interacting proteins were obtained from the STRING database. (A) Histogram of the number of interacting proteins. Five datasets are shown: known moonlighting proteins in the MPR1-3 sets (MPR-ALL), the identified moonlighting proteins in E. coli (Ecoli-MP), moonlighting proteins detected in E. coli that have clear experimental evidences for the dual functions and classified into the category 1 (Ecoli-MP-Cat1), E. coli proteins whose multi-functionality originates from different domains (Ecoli-MultiDomain) and non-moonlighting proteins in E. coli. Values on the y-axis are the fraction of the proteins among the entire proteins in each dataset. The bin size used was five. (B), average number of clusters of interacting proteins clustered using the funsim score (Eqn. 4). Seven datasets are plotted: MPR1, MPR2, MPR3, Ecoli-MP, Ecoli-MP-Cat1, Ecoli-MultiDomain, and Ecoli-nonMP. (C) Clustering was performed using the funsim score of BP terms only (Eqn. 3).