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Table 4 Pathway enrichment analysis of H. sapiens proteins involved in the predicted host-pathogen PPI dataset

From: Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions

Pathway names

p-value

 (a)

Focal adhesion

5.85E-13

Translation factors

6.61E-12

Pathways in cancer

7.51E-12

Measles

5.21E-09

Pancreatic cancer

7.44E-09

Proteasome

8.80E-09

Antigen processing and presentation

1.68E-08

Adipogenesis

3.41E-08

Myometrial relaxation and contraction pathways

5.66E-08

MAPK signaling pathway

5.82E-08

Endocytosis

5.87E-08

Integrated cancer pathway

5.89E-08

Viral myocarditis

8.03E-08

Cell cycle

8.28E-08

Leishmaniasis

1.08E-07

T cell receptor signaling pathway

1.12E-07

Tuberculosis

2.76E-07

Spliceosome

7.79E-07

Renal cell carcinoma

7.82E-07

Amoebiasis

8.28E-07

 (b)

Hepatitis C

2.03E-14

Pathways in cancer

2.52E-13

Endocytosis

3.20E-13

MAPK signaling pathway

5.66E-13

Neurotrophin signaling pathway

4.67E-12

v Cell cycle

1.78E-11

Shigellosis

4.18E-11

T cell receptor signaling pathway

3.21E-10

Senescence and autophagy

7.20E-10

NOD-like receptor signaling pathway

9.06E-10

Prostate cancer

1.35E-09

EBV LMP1 signaling

4.64E-09

RIG-I-like receptor signaling pathway

4.74E-09

Acute myeloid leukemia

2.42E-08

Osteoclast differentiation

3.37E-08

Apoptosis

3.86E-08

Chagas disease (American trypanosomiasis)

9.86E-08

Pancreatic cancer

1.03E-07

Proteasome

1.14E-07

DNA damage response

1.25E-07

  1. (a) summarizes the 20 most significantly enriched pathways for H. sapiens proteins involved in the host-pathogen PPI dataset predicted by our stringent homology-based approach.
  2. (b) summarizes the 20 most significantly enriched pathways for H. sapiens proteins involved in the host-pathogen PPI dataset predicted by the conventional homology-based approach.