Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions

Biology Direct

Table 1 Cellular compartment distribution of H. sapiens proteins targeted by the predicted host-pathogen PPIs

Cellular compartment	Percentage(%)	No. of
		proteins
(a)
GO:0048471 perinuclear region of cytoplasm	12.2	44
GO:0005730 nucleolus	7.50	27
GO:0005615 extracellular space	5.56	20
GO:0016607 nuclear speck	5.28	19
GO:0005813 centrosome	3.89	14
GO:0031965 nuclear membrane	2.78	10
GO:0005667 transcription factor complex	2.78	10
GO:0000502 proteasome complex	2.50	9
GO:0042470 melanosome	2.50	9
GO:0009897 external side of plasma membrane	2.22	8
(b)
GO:0048471 perinuclear region of cytoplasm	11.9	14
GO:0043025 neuronal cell body	5.93	7
GO:0005730 nucleolus	5.08	6
GO:0005759 mitochondrial matrix	5.08	6
GO:0016585 chromatin remodeling complex	4.24	5
GO:0005813 centrosome	3.39	4
GO:0005667 transcription factor complex	3.39	4
GO:0031965 nuclear membrane	3.39	4
GO:0017053 transcriptional repressor complex	2.54	3
GO:0005741 mitochondrial outer membrane	2.54	3

This table summarizes top 10 most frequent cellular compartments where the H. sapiens proteins (targeted by the predicted host-pathogen PPIs) likely to be located in.
(a) is cellular compartment distribution of H. sapiens proteins targeted by the stringent homology-based approach predicted host-pathogen PPIs (Top 10 cellular compartments).
(b) is cellular compartment distribution of H. sapiens proteins targeted by the conventional homology-based approach predicted host-pathogen PPIs (Top 10 cellular compartments).

ISSN: 1745-6150