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Figure 9 | Biology Direct

Figure 9

From: The Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed

Figure 9

Factorial analysis of TrpRS inter-domain effects. A. The catalytic activity of the Urzyme facilitates a full-factorial analysis of the benefits of adding either the CP1 or anticodon-binding domain, jointly with their synergistic effect in the full-length enzyme. B. Free energy histograms for the factorial design in A, showing nearly identical patterns in which the CP1 and ABD actually diminish both specificity for tryptophan vs tyrosine and acylation of tRNATrp. The entire difference between Urzyme and full-length enzyme is achieved only via the synergistic participation of both domains missing in the Urzyme.

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