Gene | Function | Length of U12 variant (in aa) | Length of U2 variant (in aa)* |
---|---|---|---|
ACTR10 | This gene encodes actin involved in microtubule-based movement. | 417 | 219 (U2-a), 219 (U2-b) |
C19orf54 | This gene encodes uncharacterized phosphoprotein. | 351 | 139 |
C1orf112 | Function unknown. | 718 | 853 (U2-a), 606 (U2-b) |
C3orf17 | Function unknown. | 567 | 392 (U2-a), 400 (U2-b) |
CTNNBL1 | Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity. | 563 | 376 |
CUL4A | This gene encodes ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins. | 789 | 149 |
ESRP1 | This gene encodes RNA-binding protein that is an epithelial cell-type-specific splicing regulator. | 742 | 206 |
HNRPLL | This gene encodes RNA-binding protein regulating activation-induced alternative splicing in T cells. | 537 | 536 |
NCBP2 | Component of the cap-binding complex (CBC), which binds to the monomethylated 5′ cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3′-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. | 156 | 103 |
PCID2 | This gene is expressed in immature and early-stage B lymphocytes and regulates expression of the mitotic checkpoint protein MAD2. | 399 | 453 (U2-a), 292 (U2-b) |
PRMT1 | This gene encodes arginine methyltransferase that is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. | NMD | 371 (U2-a), 353 (U2-b), 346 (U2-c), 325 (U2-d), 213 (U2-e), 192 (U2-f) |
SLC9A7 | This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. It is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. | 725 | 727 |
SPAG16 | This gene encodes protein kinase binding protein associated with the axoneme of sperm tail. | 631 | 577 |
SSR3 | This gene encodes the gamma subunit of glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. | 198 | 174 |
TAPT1 | This gene encodes a highly conserved, putative transmembrane protein. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton, which are similar to the phenotype of mouse homeobox C8 gene mutants. | 567 | 338 |
TTLL9 | This gene encodes a tubulin tyrosine ligase-like protein that forms polyglutamate side chains on tubulin. | 347 | 439 |
UBE2H | This gene encodes a member of the ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. | 183 | 149 |
ZNF207 | This gene encodes uncharacterized zing finger protein expressed in cultured breast cancer cells. | 494 | 95 (U2-a), 74 (U2-b) |