Table 4 Correlation of CvP-bias differences with experimentally determined Tm value differences for various orthologous protein pairs

Rrp4 (A. pompejana vs. human)

CvP-bias

0.408

6.122

5.714

Tm

38°C

43.1°C

5.1

Pol η (A. pompejana vs. human)

CvP-bias

5.71

3.67

−2.04

Tm

49°C

43°C

−6

Collagen (A. pompejana vs. human)

CvP-bias

8.696

5.804

−2.892

Tm

45-46°C

38-42°C

−3 to −8

U2AF65 (A. pompejana vs. human)

CvP-bias

11.90

5.68

−6.22

Tm

47°C

43°C

−4

Nup170 (C. thermophilum vs. S. cerevisiae)

CvP-bias

−1.13

−4.86

−3.73

Tm

57°C

36°C

−21

Nup192 (C. thermophilum vs. S. cerevisiae)

CvP-bias

3.47

−3.33

−6.8

Tm

57°C

36°C

−21

Xylanase (C. thermophilum vs. Trichoderma reesei)

CvP-bias

−20.276

−22.523

−2.24

Tm

60°C

50°C

−10