TY - JOUR AU - Anantharaman, Vivek AU - Makarova, Kira S. AU - Burroughs, A. Maxwell AU - Koonin, Eugene V. AU - Aravind, L. PY - 2013 DA - 2013/06/15 TI - Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing JO - Biology Direct SP - 15 VL - 8 IS - 1 AB - The major role of enzymatic toxins that target nucleic acids in biological conflicts at all levels has become increasingly apparent thanks in large part to the advances of comparative genomics. Typically, toxins evolve rapidly hampering the identification of these proteins by sequence analysis. Here we analyze an unexpectedly widespread superfamily of toxin domains most of which possess RNase activity. SN - 1745-6150 UR - https://doi.org/10.1186/1745-6150-8-15 DO - 10.1186/1745-6150-8-15 ID - Anantharaman2013 ER -