Computer simulation of the re-methylation kinetics in (a) non-CIMP and (b) CIMP cells, according to the mathematical model described in the text. 5-AZA treatment is indicated by the arrow. The solid line represents the methylation level of an individual locus, x, while the dashed line represents de novo MTase activity, y
. Parameters were chosen as follows. (a) λ = 0.4; k
= 0.04; a
= 4; g = 80; k
= 100; a
= 0.4 η = 2; c = 10; q = 0.8; b = 4000; (b) same, but η = 2.