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Figure 4 | Biology Direct

Figure 4

From: Methylation kinetics and CpG-island methylator phenotyope status in colorectal cancer cell lines

Figure 4

Computer simulation of the re-methylation kinetics in (a) non-CIMP and (b) CIMP cells, according to the mathematical model described in the text. 5-AZA treatment is indicated by the arrow. The solid line represents the methylation level of an individual locus, x, while the dashed line represents de novo MTase activity, y n . Parameters were chosen as follows. (a) λ = 0.4; k 1 = 0.04; a 1 = 4; g = 80; k 2 = 100; a 2 = 0.4 η = 2; c = 10; q = 0.8; b = 4000; (b) same, but η = 2.

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