Figure 6
From: Reaction-Diffusion-Delay Model for EPO/TNF-α Interaction in articular cartilage lesion abatement
Healthy and Penumbra cells with EPO. This figure shows the evolution of the healthy and penumbra cell population densities over a period of 10 days. Initially there is the development of a population of penumbra cells (c) due to the time lags for EPO production and EPOR activation. However, once healthy cells at the edge of the penumbra begin to produce EPO and penumbra cells become EPOR active there is an increase in the population density of healthy cells near the injury and there ceases to be expansion of the penumbra ((d) - (i)).