Figure 5
From: Reaction-Diffusion-Delay Model for EPO/TNF-α Interaction in articular cartilage lesion abatement
Healthy and Penumbra cells without EPO. This figure shows the evolution of the healthy and penumbra (comprised of both catabolic and EPOR active) cell population densities over a period of 10 days. The results shown here correspond to a situation in which there is no production of or response to EPO. We see here that the healthy cell population is decimated. In accord with figure 4 and the corresponding mathematical model (equations (3-11)) this is due to the uninhibited influence of pro-inflammatory cytokines.