From: Modeling RNA polymerase interaction in mitochondria of chordates
Solution parameters for healthy human | Transcription levels (relative to ND1 gene) in the model (1st row) and experiment (2nd row) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
LSP | HSP1 | HSP2 | mTERF | R | L 1 n | ND2 | COX1 | COX2 | ATP6/8 | ND3 | ND5 | CYTB |
0.0031 | 0.0031 | 0.0126 | 0.6456 | 23.955 | 1.945 | 1.00 | 1.00 | 1.00 | 0.96 | 0.96 | 0.96 | 0.96 |
Experimental estimates | Transcription level: | 1.40 | 1.04 | 1.72 | 0.91 | 1.04 | 1.86 | 2.31 | ||||
Error (if statistically independent): | ±0.23 (1.8) | ±0.52 (0.1) | ±0.61 (1.2) | ±0.43 (0.1) | ±0.12 (0.7) | ±0.56 (1.6) | ±0.56 (2.4) | |||||
Error (if statistically dependent): | ±0.40 (1.0) | ±0.82 (0.1) | ±0.95 (0.8) | ±0.71 (0.1) | ±0.20 (0.4) | ±0.99 (0.9) | ±1.01 (1.3) | |||||
Deviation from the experiment,%: | −29 | −4 | −42 | +5 | −4 | −48 | −58 | |||||
Solution parameters for MELAS case | Changes of transcription levels in the model | |||||||||||
Phe | 12 S | Val | 16 S | Leu | Lys | CYTB | ||||||
0.0031 | 0.0004 | 0.0126 | 0.5336 | 24.333 | 3.84 | 1.20 | 1.20 | 1.20 | 1.16 | 1.22 | 1.17 |