Table 6 Selected common pathways between van de Vijver and Wang datasets (all enriched for breast cancer non-metastasis; bold for those enriched for metastasis)
Common pathways for non-metastasis (or metastasis in bold) | Function of pathway |
|---|---|
HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES | Coagulation inhibits lung cancer metastasis in animal studies [54] A part of innate immune system and an effector of antibody-mediated immunity [55] |
HSA00100_BIOSYNTHESIS_OF_STEROIDS | Found in metastatic tissue [56] and related with feminizing syndromes [57] |
HSA04110_CELL_CYCLE | Related with cell growth and cell death |