Figure 3
From: Structure based hypothesis of a mitochondrial ribosome rescue mechanism
mtRF1 is proposed to be a ribosomal rescue factor. (A) mtRF1 is proposed to bind to ribosomes stalled on mRNA lacking a stop codon and with an A-site devoid of mRNA. This allows for binding of mtRF1, followed by release of the nascent peptide chain. (B) This in contrast to mtRF1a, which only releases the nascent peptide when a stop codon is present in the A-site.