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Table 2 Conservation profile of pre-miRs containing conserved TFBS (z-score ≥ 2.33).

From: Transcription factor binding sites are highly enriched within microRNA precursor sequences

  Primate Mammal Vertebrate Row total
Pre-miRs containing TFBS 9 40 69 118
Pre-miRs lacking TFBS 316 146 119 581
Column total 325 186 188 699
  1. "Primate" lineage indicated here includes miRNAs that have pre-miR homologues in non-primate species but which do not match the mature human miRNA sequence exactly. The lineage distribution is extremely different between pre-miRs that contain vs. those that lack TFBS (χ2 = 101.59, p = 0).