Figure 4
From: CREST - a large and diverse superfamily of putative transmembrane hydrolases
A diagram of predicted core transmembrane segments and domain diagrams of CREST proteins. (a) A cartoon diagram showing the seven predicted core transmembrane segments of CREST proteins. The N- and C-termini are labeled. The predicted core transmembrane segments (TM) are labeled 1-7 from the N-terminus to the C-terminus. TM7 is placed as neighboring to TM2 and TM3 to reflect possible spatial closeness among TM2, TM3 and TM7 that harbor motifs with conserved putative active site residues (shown inside them). (b) Domain diagrams of representative CREST members. NCBI gene identification numbers and annotations are shown beside the domain diagrams. Species names are shown in brackets. The last five proteins are from hypothetical groups 1-5, respectively.