Figure 1

An example of a RGC_CA used in this study. The data are for KOG0100 (heat shock proteins). Using the notation described under Methods, P1 = ... = P10 = At = Os = Pp ≠ Dm = Ag = Hs = Ce = Gg = Sc = Sp. The ancestral amino acid is shown in red, the opisthokont-specific substitution is shown in green. The corresponding codons extracted from the underlying nucleotide sequence alignments are shown in parentheses. Species abbreviations: Homo sapiens (Hs), Caenorhabditis elegans (Ce), Drosophila melanogaster (Dm), Saccharomyces cerevisiae (Sc), Schizosaccharomyces pombe (Sp), Arabidopsis thaliana (At), Anopheles gambiae (Ag), Oryza sativa (Os), Physcomitrella patens (Pp), Gallus gallus (Gg), and 10 outgroup prokaryotic species (P1...P10).