Impact of Alu repeats on the evolution of human p53 binding sites

Biology Direct

Table 2 Summary of p53 motifs found in selected Alu subfamilies

Name^a	# Alu elements^b	# p53 motifs^c	S = 0^d	S = 3^d	S = 8^d	S = 14
FLAM-A	18264	5484	633	233	2080	1057
FLAM-C	35888	14083	1786	804	5036	3923
AluJo	137954	75938	13745	4424	20989	14007
AluJb	126856	62528	12542	11954	4297	9560
AluSx	333710	129530	32361	42879	8104	16192
AluSq	93874	30593	7253	12164	409	4445
AluSg	84797	30561	9593	6280	3608	3136
AluSp	50857	21429	13340	1904	127	2036
AluSc	43135	6884	2945	864	293	92
AluSg1	6130	4429	3570	72	186	200
AluY^e	139813	12488	1753	512	2542	360
Total	1071278	393947	99521	82090	47671	55008

^a The Alu subfamilies are ordered by age [80–82, 73]. Only subfamilies with the number of p53 motifs exceeding 4000 are presented.
^b The Alu elements are collected from AluGene database [65].
^c The p53 motifs with the spacer, S = 0-14 bp, and with PWM-20 scores ≥ 70% are counted.
^d The numbers of p53 motifs with spacer S = 0, 3, 8, 14 bp are presented. For each subfamily (except AluY), the data corresponding to the prevalent spacers S are highlighted in boldface and underlined.
^e For the AluY subfamily, the prevalent spacer is S = 2 with 4588 p53 motifs (Additional File 4: Figure S4-I).

ISSN: 1745-6150