|
Target Site
|
Example drugs
|
|---|
|
23s RNA between L22 and L4
|
Macrolides[106] and PTF inhibitors [105]
|
|
RNA Polymerase
|
GE23077[130]
|
|
EF-Tu
|
Kirromycin [131]
|
- These drugs bind targets sites present in both bacteria and archaea (or eukaryotes), but with very different affinities. We argue this is a molecular fossil of the unique antibiotic war that resulted in the origin of archaea.
