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Table 4 Functional enrichment of fast-evolving and slow-evolving genes in rodents.

From: Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes

Fast-evolving genes
ID Category Name guiniea pig mouse rat
MF00250 Serine protease inhibitor * * *
MF00006 Interleukin receptor   * *
BP00117 JAK-STAT cascade   * *
Slow-evolving genes
MF00261 Actin binding cytoskeletal protein * * *
MF00264 Microtubule family cytoskeletal protein * * *
MF00009 Glutamate receptor * *  
MF00008 Ligand-gated ion channel * *  
MF00024 Ion channel * *  
MF00069 Ribonucleoprotein * *  
BP00051 mRNA end-processing and stability *   
BP00126 Exocytosis   * *
BP00246 Ectoderm development   * *
BP00137 Protein targeting and localization   *  
MF00052 DNA-directed RNA polymerase   *  
MF00156 Other hydrolase   *  
BP00199 Neurogenesis   * *
BP00133 Nuclear transport    *
BP00066 Protein acetylation    *
P05911 Angiotensin II-stimulated signaling through G proteins and beta-arrestin   * *
P00007 Axon guidance mediated by semaphorins   * *
P05731 GABA-B receptor II signaling   *  
P05913 Enkephalin release   *  
P00038 JAK/STAT signaling pathway    *
P05734 Synaptic vesicle trafficking    *
  1. Note: The asterisks depict functional classifications of genes that are significantly enriched based on Fisher's Exact Test after multiple corrections among rodents.