Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes

Table 2 Functional enrichment of fast-evolving and slow-evolving genes in primates.

Fast-evolving genes
ID	Category Name	chimp	orangutan	macaque
BP00183	Chemosensory perception	*	*
BP00184	Olfaction	*	*
MF00002	G-protein coupled receptor	*
BP00182	Sensory perception	*
BP00281	Oncogenesis	*
BP00283	Other oncogenesis	*
MF00175	Major histocompatibility complex antigen	*
MF00198	Structural protein	*
MF00256	Intermediate filament	*
BP00124	Cell adhesion			*
Slow-evolving genes
BP00114	MAPKKK cascade	*
MF00001	Receptor	*
MF00113	Phosphatase	*
BP00029	Lipid and fatty acid binding	*
BP00134	Mitochondrial transport		*
MF00188	Select calcium binding protein		*
MF00218	Calmodulin related protein		*
MF00079	Other chaperones		*
MF00098	Large G-protein			*
P00052	TGF-beta signaling pathway			*

Note: The asterisks depict functional classifications of genes that are significantly enriched based on Fisher's Exact Test after multiple corrections among primates.

ISSN: 1745-6150