Table 3 Average frequency of minor alleles.
From: Mitochondrial pathogenic mutations are population-specific
SNP Category | African (401 genomes) | Non-African (4057genomes) | Non-African (Monte-Carlo sampling of 401 genomes) | U-test p-value |
|---|---|---|---|---|
Synonymous | 0.027 ± 0.003 | 0.0040 ± 0.0004 | 0.011 ± 4 × 10-6 | 7.9 × 10-6 |
- Four fold | 0.029 ± 0.004 | 0.0039 ± 0.0005 | 0.011 ± 4 × 10-6 | 2.4 × 10-6 |
Nonsynonymous | 0.023 ± 0.005 | 0.0033 ± 0.0006 | 0.011 ± 4 × 10-6 | 1.5 × 10-6 |
- Benign | 0.026 ± 0.006 | 0.0042 ± 0.0008 | 0.012 ± 5 × 10-6 | 1.0 × 10-6 |
- Damaging | 0.0089 ± 0.009 | 0.00082 ± 9 × 10-5 | 0.0038 ± 3 × 10-6 | 1.7 × 10-3 |
Pathogenic total | 0.0077 ± 0.003 | 0.0037 ± 0.001 | 0.0084 ± 8 × 10-6 | 1.0 × 10-6 |
- Coding regions | 0.0074 ± 0.003 | 0.0044 ± 0.001 | 0.0095 ± 1 × 10-5 | 1.0 × 10-6 |