Figure 1From: The ancient function of RB-E2F Pathway: insights from its evolutionary historyDistribution of RB-E2F proteins in 21 representative Eukaryotic organisms. The gene number of E2F1-6, E2F7/8, RB, and DP family in 20 representative Eukaryotic organisms were listed. M. brevicollis, D. discoideum, and O. tauri are unicellular organisms. The phylogenetic relationship of these organisms was drawn according to the results of proteome-based phylogeny [12, 15]. The accession numbers and sequences of all these proteins are listed in additional File 1Back to article page