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Table 2 Parameter values used for simulation

From: A kinetic model of TBP auto-regulation exhibits bistability

Parameter value

Reference

k1 = 1*105 M-1s-1

[17]

k2 = 1*10-3 s-1

[17]

k3 = 2*105 M-1s-1

[17, 19, 36]

k4 = 4*10-4 s-1

[36]

k5 = 5*10-13 Ms-1

From [37] and k8

k7 = 1.25*10-8M

Half of D0

k8 = 7.4*10-5 s-1

[20]

k6 = 2

Assumed

k0 = 5*10-15 Ms-1

Assumed (0.01*k5)

[D0] = 2.5*10-8 M

[34]