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Figure 2 | Biology Direct

Figure 2

From: Co-lethality studied as an asset against viral drug escape: the HIV protease case

Figure 2

locked targets (accessible, spatially close locked sets). All nodes shown here are accessible and spatially close amino acids The nodes in ovals are the accessible synthetic lethals which were shaded in blue on Figure 1, boxed with the same colour codes and linked by black edges. Each black edge means "is co-lethal with, and within 10 Angström from". The corresponding p-value is shown above each edge. Invariant amino acids are boxed in green, linked by dotted green edges meaning "is within 10 Angström from". All the nodes are shaded in blue because they are all accessible. Each invariant is also linked to all the other nodes by implicit edges, not shown, for the sake of clarity. The locked target represented subgraph "a" is called SGI flap (orange+green) The locked target represented subgraph "b" is called SGI canti (red+green) The locked target represented subgraph "c" is called SGI fulc (yellow+green) The graph was built using the Graphviz software.

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