Figure 1
From: Co-lethality studied as an asset against viral drug escape: the HIV protease case
Spatially close SLs. The whole graph represents the "spatially close SLs". The blue-shaded ovals, represents only the "accessible, spatially close SLs". Each oval contains the amino acid (one-letter codename) found in the HIV-1 protease ancestral sequence, followed by its position in this sequence. The accessible residues are all shaded in blue. The black edges linking the nodes mean "is co-lethal with and is within 10 Angström from". The four orange, boxed amino acids (N37, P39, K41, D60) are the locked targets jointly called SG flap. The three red, boxed amino acids (H69, K70, I72) are the locked targets called SG canti. The two yellow, boxed amino acids (L10, T12) are the locked targets called SG fulc1 and the two yellow double-boxed amino acids (K14, L19) are the locked targets called SG fulc2. SG fulc1 plus SG fulc2 are called all together SG fulc. The graph was built with Graphviz software.