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Table 4 Correlations of lengths of intergene spacer between processed antisense tRNAs and the next gene with misacylation potential and cloverleaf stability of antisense tRNAs.

From: Undetected antisense tRNAs in mitochondrial genomes?

 

Misacylation-interspacer

COVE-interspacer

resCOVE-interspacer

tRNA

r

P

rs

P

r

P

rs

P

r

P

rs

P

Ala

-0.157

0.167

-0.196

0.113

-0.198

0.086

-0.196

0.089

-0.073

0.308

-0.063

0.334

Asp

0.081

0.304

0.298

0.026

-0.229

0.057

-0.208

0.076

-0.374

0.004$

-0.36

0.006

Gln

0.152

0.191

0.18

0.15

0.36

0.006

0.331

0.01

0.314

0.014

0.288

0.022

Glu

0.144

0.179

0.25

0.053

-0.092

0.264

-0.13

0.187

-0.225

0.06

-0.239

0.049

Ile

0.047

0.377

-0.135

0.185

0.009

0.477

-0.013

0.464

-0.043

0.384

-0.047

0.374

Met

-0.058

0.346

0.009

0.476

0.273

0.029

0.242

0.047

0.119

0.207

0.118

0.209

Pro

0.182

0.121

0.362

0.009$

-0.412

0.002$

-0.224

0.06

-0.435

0.001$

-0.265

0.033

Ser UCN

-0.122

0.256

0.008

0.484

-0.335

0.009

-0.324

0.012

-0.04

0.391

-0.032

0.415

Thr

-0.195

0.135

-0.196

0.134

0.099

0.248

0.063

0.334

0.0001

0.498

-0.04

0.392

Trp

0.45

0.001$

0.511

0.000$

0.031

0.416

0.034

0.408

-0.009

0.474

-0.001

0.496

Tyr

-0.112

0.254

-0.109

0.26

0.087

0.276

0.155

0.144

0.174

0.116

0.224

0.061

Combined χ2

 

35.78

 

51.28

 

48.00

 

35.86

 

50.82

 

33.71

Combined P

 

0.032

 

0.0004

 

0.0011

 

0.031

 

0.0005

 

0.0525

  1. Correlations are for homologous tRNAs from 49 primate genomes, but exclude antisense tRNAs with non-symmetric anticodons (see text for explanations). Misacylation, COVE and residual COVE are as in Table 3. Both parametric Pearson (r) and non-parametric Spearman rank (rs) correlation coefficients and their statistical one sided significances are indicated. The two last rows indicate results of Fisher's method for combining P values. Bold indicates P < 0.05, $ indicates statistical significance at P < 0.05 after Bonferroni's adjustment for multiple tests.