Figure 1

Scheme of the human mitochondrial genome region templating for sense tRNAs Ser UGA and Asp GUC. Continuous lines indicate expressed sense genes, dashed lines hypothetically expressed antisense genes. tRNAs are indicated by their cognate amino acid, followed by the anticodon detected by tRNAscan-SE http://lowelab.ucsc.edu/tRNAscan-SE/ and the structural component of the Cove index of that tRNA. Hypothetical antisense tRNAs are in italics. Gene positions on the mitochondrial genome are indicated according to the standard in Genbank (NC_012920). The 5' flank of the antisense of tRNA Ser UGA is processed by sense RNA maturation by default because it is flanked by the mitochondrial protein coding gene COX1, its 3' flank because of its vicinity with sense tRNA Asp GUC. Normal sense RNA maturation processes only the 3' flank of the hypothetical antisense of sense tRNA Asp GUC. Extremities of tRNAs and their anticodons are as detected for these sequences by tRNAscan-SE.