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Table 4 Distinct phyletic patterns of non-homologous isofunctional enzymes

From: Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

Enzyme (EC) Examples Instances in bacteria (out of 607) Instances in archaea (out of 48) Instances in eukaryotes (out of 63)
Superoxide dismutase (EC 1.15.1.1) SODF_ECOLI 526 23 62
  SODC_ECOLI 249 3 47
  SODN_STRSO 32 0 1
  NEC1_NICLS 6 0 3
Heme oxygenase (EC 1.14.99.3) HMOX1_HUMAN 134 0 41
  ISDI_STAAR 36 0 0
Shikimate kinase (EC 2.7.1.71) AROL_ECOLI 553 9 28
  AROK_METJA 0 39 0
Diacylglycerol kinase (EC 2.7.1.107) KDGL_ECOLI 404 0 0
  DGKG_HUMAN 23 0 59
Fructose bisphosphatase (EC 3.1.3.11) F16PA_ECOLI 268 5 54
  F16P_BACSU 307 4 2
  Q8U359_PYRFU 19 37 0
Carbonic anhydrase (EC 4.2.1.1) CYNT_ECOLI 414 17 35
  CAH_METTE 211 32 10
  CAH1_HUMAN 88 0 40
Glucose-6-phosphate isomerase (EC 5.3.1.9) G6PI_HUMAN 547 10 58
  G6PI_THELI 11 13 0
Lysine---tRNA ligase (EC 6.1.1.6) SYK1_ECOLI 551 15 63
  SYK_AERPE 91 36 0
  1. The data are from the ortholog tables in the KEGG database [20], supplemented with the results of iterative BLAST searches against the NCBI's Reference Sequence database [56].