Structural analysis of YjeA protein family. A- Three dimensional structure of YjeA from Salmonella typhimurium (PDB: 3G1Z) in pink and class II lysyl-tRNA synthetase (LysRS) from Escherichia coli  (PDB: 1BBU) in purple. The domains that constitute LysRS are indicated: catalytic core and anticodon binding domain (ABD). B- Merging of the two previous global structures and zoom into the active site and catalytic residues. The residues responsible for lysine binding are in pink for YjeA and in purple for the LysRS2. The lysine substrate present in LysRS2 structure is indicated in orange and the AMP present in YjeA structure is indicated in yellow. Red circles highlight the residues for which the 3 dimensional positions are not conserved.