Table 3 Estimates of Parameters for Each Pathway

Mutation Rate

1.4E-06

2.2E-04

3.2E-03

1.2E-06

± 1.69E-08

± 1.32E-05

± 3.33E-04

± 2.06E-07

Proliferation Rate

0

0

3.6E-03

1.6E-02

N/A

N/A

± 1.12E-03

± 4.78E-04

Birth Rate Para.

0

0

7.4E-03

1.9E-02

N/A

N/A

± 1.03E-03

± 4.08E-04

Growth Limiting Para.

N/A

N/A

8.3E-05

N/A

N/A

N/A

± 1.4E-05

N/A

MSI Pathway

J ₀

J ₁

J ₂

J ₃

J ₄

Mutation Rate

8.3E-07

3.5E-04

1.4E-03

9.3E-03

7.7E-06

± 1.38E-08

± 1.89E-05

± 8.57E-05

± 1.22E-03

± 1.7 9E-06

Proliferation Rate

0

0

0

2.8E-03

2.0E-02

N/A

N/A

N/A

± 7.01E-04

± 3.31E-04

Birth Rate

0

0

0

9.6E-03

2.6E-02

N/A

N/A

N/A

± 6.08E-04

± 2.88E-04

Growth Limiting Para.

N/A

N/A

N/A

1.6E-03

N/A

N/A

N/A

N/A

± 3.7E-04

N/A