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Table 1 Constants and values used in model

From: A theoretical quantitative model for evolution of cancer chemotherapy resistance

Constant Value Reference
H+ diffusion coefficient 1.08 × 10-5 cm2/s [24]
O2 diffusion coefficient 1.46 × 10-5 cm2/s [25]
Glucose diffusion coefficient 5 × 10-6 cm2/s [26]
O2 uptake rate 9.41 × 10-2 × [O2]/s [27]
Glucose uptake rate 5 × 10-5 × [Glc]/s [24]
Quiescence pH threshold for normal cells 7.1 [28]
Death pH threshold for normal cells 6.8 [28]
Mutation rate for tumor cells 0.1% [28]
ATP production for 100% probability of cell duplication. 8.6 × 10-6 M/s [29]
Minimum ATP production for cell survival. 8.6 × 10-7 M/s [29]