From: A theoretical quantitative model for evolution of cancer chemotherapy resistance
Constant | Value | Reference |
---|---|---|
H+ diffusion coefficient | 1.08 × 10-5 cm2/s | [24] |
O2 diffusion coefficient | 1.46 × 10-5 cm2/s | [25] |
Glucose diffusion coefficient | 5 × 10-6 cm2/s | [26] |
O2 uptake rate | 9.41 × 10-2 × [O2]/s | [27] |
Glucose uptake rate | 5 × 10-5 × [Glc]/s | [24] |
Quiescence pH threshold for normal cells | 7.1 | [28] |
Death pH threshold for normal cells | 6.8 | [28] |
Mutation rate for tumor cells | 0.1% | [28] |
ATP production for 100% probability of cell duplication. | 8.6 × 10-6 M/s | [29] |
Minimum ATP production for cell survival. | 8.6 × 10-7 M/s | [29] |