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Table 1 Constants and values used in model

From: A theoretical quantitative model for evolution of cancer chemotherapy resistance

Constant

Value

Reference

H+ diffusion coefficient

1.08 × 10-5 cm2/s

[24]

O2 diffusion coefficient

1.46 × 10-5 cm2/s

[25]

Glucose diffusion coefficient

5 × 10-6 cm2/s

[26]

O2 uptake rate

9.41 × 10-2 × [O2]/s

[27]

Glucose uptake rate

5 × 10-5 × [Glc]/s

[24]

Quiescence pH threshold for normal cells

7.1

[28]

Death pH threshold for normal cells

6.8

[28]

Mutation rate for tumor cells

0.1%

[28]

ATP production for 100% probability of cell duplication.

8.6 × 10-6 M/s

[29]

Minimum ATP production for cell survival.

8.6 × 10-7 M/s

[29]