Growth pattern of untreated tumor at generation 39. Growth pattern of untreated tumor at generation 39. A shows chemosensitive cells (green) and chemoresistant cells (red). B shows distribution of glycolytic phenotype: cells closer to green have slower metabolic rate and those closer to red are more glucose avid. C shows distribution of acid resistance, the closer to red the more resistant and the ones closer to green are more sensitive to low pHe. D shows cells in low pHe induced quiescent state in green and proliferative cells in yellow.