Figure 3
From: A theoretical quantitative model for evolution of cancer chemotherapy resistance
Average tumor chemoresistance for untreated (CONTROL), maximum tolerated dose treatment (MTD) and 2-deoxy-glucose only treatment (2DG). Average tumor chemoresistance for untreated (CONTROL), maximum tolerated dose treatment (MTD) and 2-deoxy-glucose only treatment (2DG). Only tumor treated with chemotherapy will "develop" chemoresistance to treatment as the treatment will change adaptive landscape of tumor to favor cells with resistant phenotype. In fact, the untreated tumor also contains resistant cells but these are kept in small numbers in absence of therapy.