Table 2 Growth Model Parameters. Parameters and baseline values for the prostate growth model.
From: The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model
Parameter | Meaning | Value |
|---|---|---|
θ 1 | Half-maximal C t for low androgen induced ROS | 30 nM |
θ 2 | Half-maximal C t for high androgen induced ROS | 225 nM |
μ | Background ROS level | .05 |
n | Hill coefficient for low androgen induced ROS | 4 |
m | Hill coefficient for high androgen induced ROS | 4 |
φ 1 | Half maximal C t for high androgen induced proliferation | 110 nM |
φ 2 | Half maximal C t for low androgen induced apoptosis | 40 nM |
Ï• | Determines form of ROS induced proliferation signal | 4 |
ω | Half-maximal S for ROS induced death | 1 |
q | Hill coefficient for ROS induced death | 8 |
σ | Mass action coefficient for proliferation attenuation | 1.5 × 10-10 cell-1 hour-1 |
δ | Background death rate | .004 hour-1 |
r | Maximum per capita growth rate | ln(2)/24 hour-1 |
δ | Maximum per capita death rate | ln(2)/24 hour-1 |