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Table 1 AR Kinetics Parameters. Parameters and baseline values for the AR kinetics model.

From: The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model

Parameter

Meaning

Value

Reference

T:AR rate of association

.14 nM -1hr -1

[80]

T:AR dissociation rate

.069 hr-1

[80]

DHT:AR rate of association

.053 nM-1 hr -1

[80]

DHT:AR dissociation rate

.018 hr -1

[80]

β R

Free AR degradation rate

ln(2)/3 hr -1

[82]

β T

Free T degradation rate

ln(2)/3 hr -1

 

β D

Free DHT degradation rate

ln(2)/9 hr -1

[61], see text

α

5α-reductase concentration

5.0 mg L -1

see text

k cat

Rate of T → DHT conversion by 5α-R

18 ± 15 nmol hr -1 mg -1

[97]

K M

Michaelis constant for 5α-R

75 ± 33 nM

[97]

K I

Michaelis constant for finasteride

.46 ± .21 nM

[97]