From: The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model
Parameter | Meaning | Value | Reference |
---|---|---|---|
| T:AR rate of association | .14 nM -1hr -1 | [80] |
| T:AR dissociation rate | .069 hr-1 | [80] |
| DHT:AR rate of association | .053 nM-1 hr -1 | [80] |
| DHT:AR dissociation rate | .018 hr -1 | [80] |
β R | Free AR degradation rate | ln(2)/3 hr -1 | [82] |
β T | Free T degradation rate | ln(2)/3 hr -1 |  |
β D | Free DHT degradation rate | ln(2)/9 hr -1 | [61], see text |
α | 5α-reductase concentration | 5.0 mg L -1 | see text |
k cat | Rate of T → DHT conversion by 5α-R | 18 ± 15 nmol hr -1 mg -1 | [97] |
K M | Michaelis constant for 5α-R | 75 ± 33 nM | [97] |
K I | Michaelis constant for finasteride | .46 ± .21 nM | [97] |