Figure 8

Observed colon cancer rate (and 95% CI, adjusted for overdispersion) and model predicted rates for the Caucasian male and female population, taken from Little et al . [6]. Rates are those predicted by the (single multiplicity) models with two cancer-stage mutations and one destabilizing mutation and three cancer-stage mutations and one destabilizing mutation. Also shown are the predicted rates for the models with two cancer-stage mutations with multiplicity two and (1-1) destabilizing mutations (i.e. 2-2-(1-1)), with multiplicity two and (1-2) destabilizing mutations (i.e. 2-2-(1-2)) and with multiplicity three and (1-1-1) destabilizing mutations (i.e. 2-3-(1-1-1)). The stem cell population is fixed at 10⁸ cells [166].