A) A classification scheme for the PC-Esterase proteins. Each family is represented by an ellipse while the higher level relationships like the groups and the core cluster are represented as ellipses surrounding them. The outer circle represents the classical GDSL/SGNH domains. The PSI-BLAST e-values provide a numerical measure of these relationships - each subfamily recovers other members of the same family at e-values in the range of 10-64-10-7 within a single iteration; the member of any group are recovered by members of other groups in multiple iterations. The domain architecture representative of each family is shown along with the gene name and organism. The phyletic pattern of the family is given and any lineage specific expansion is shown in red. The class abbreviations are Cho - Chordates, Cru - crustacea, Ann -annelid, Fun - Fungi, Asc - Ascomycota, Basi - Basidomycota, B-Fun - Basal Fungi, Ani -Animals, Ech - echinodermata, Mol - molluscs, Cni - cnidaria, Nem - Nematoda, Pla - Plants, Chl - Chlorophytes, Str - Stramenopiles, Hap - Haptophyceae, and the species abbreviations are as above. B) Domain architectures of the Cadherin-like domainsThe domain architectures of the Cadherin-like (Cad-L) domains are shown. The gene name, Organism name and gi are given below. The phyletic pattern is also given, if the architecture is widespread. Domain abbreviations: Fn3 - Fibronectin 3; CBM - Carbohydrate binding domain; LamGL - LamG like jelly roll domain; CWB - Cell Wall Binding repeats.