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Table 3 Regulatory Rho-family small GTPases involved in phagocytosisa

From: The origins of phagocytosis and eukaryogenesis

Protein family; a representative (GI)

Detection in proteomic studies (number of species, out of 5 studied)

Role in phagocytosis

Domain architecture (with CDD IDs)band structural features (N-C)c

Range of orthologs in eukaryotes

Prokaryotic homologs

References

Cdc42

45384262

1 (mouse)

Regulates actin remodeling in Fc-mediated and AC-mediated phagocytosis, and micropinocytosis but not CR-mediated phagocytosis

Rho (Ras homology) family of Ras-like GTPases: Cdc42 subfamily (cd01874)

Animals, fungi, and Choanoflagellida

Orthologous relationships are hard to determine but numerous bacteria and some archaea encode diverse small GTPases

[94, 121, 92, 25]

[93]

[101]

CED-10 [95]

Rac/RhoG/CED-10

2702398

4 (except for Tetrahymena)

 

Rho family of Ras-like GTPases (cd00157)

All eukaryotes except for Apicomplexa and Kinetoplastida

  

RhoA

2225894

2 (mouse and Drosophila)

Regulates actin remodeling in CR-mediated phagocytosis; not required for or inhibits other types of phagocytosis

Ras-like GTPases: RhoA-like subfamily (cd01870)

Animals, fungi, and Choanoflagellida

 

[97, 98, 102]

  1. aOnly proteins whose role in phagocytosis was characterized in detail are included.
  2. bThe domain identifier from the Conserved Domain Database [96] is given in parentheses.
  3. cThe domains are listed from the N-terminus to the C-terminus of the respective protein.