Protein family; a representative (GI) | Detection in proteomic studies (number of species, out of 5 studied) | Role in phagocytosis | Domain architecture (with CDD IDs)band structural features (N-C)c | Range of orthologs in eukaryotes | Prokaryotic homologs | References |
---|---|---|---|---|---|---|
Cdc42 45384262 | 1 (mouse) | Regulates actin remodeling in Fc-mediated and AC-mediated phagocytosis, and micropinocytosis but not CR-mediated phagocytosis | Rho (Ras homology) family of Ras-like GTPases: Cdc42 subfamily (cd01874) | Animals, fungi, and Choanoflagellida | Orthologous relationships are hard to determine but numerous bacteria and some archaea encode diverse small GTPases | [93] [101] CED-10 [95] |
Rac/RhoG/CED-10 2702398 | 4 (except for Tetrahymena) | Â | Rho family of Ras-like GTPases (cd00157) | All eukaryotes except for Apicomplexa and Kinetoplastida | Â | Â |
RhoA 2225894 | 2 (mouse and Drosophila) | Regulates actin remodeling in CR-mediated phagocytosis; not required for or inhibits other types of phagocytosis | Ras-like GTPases: RhoA-like subfamily (cd01870) | Animals, fungi, and Choanoflagellida | Â |