Skip to main content

Table 2 Factors contributing to the variability in expression of the proteasome genes.

From: Epigenetic hereditary transcription profiles III, evidence for an epigenetic network resulting in gender, tissue and age-specific variation in overall transcription

A. Database

 

Contents

Variance

df

percentage of variance

Database AA

 

raw date transformed to a mean of 1000 per probe

   
 

M females

 

94652,5

1549

100,0

 

M males

 

81873,5

2293

100,0

 

V females

 

110677,7

681

100,0

 

V males

 

79961,4

495

100,0

Database BB

 

additionally:proteasome expression level removed

   
 

M females

 

50437,8

1549

53,3

 

M males

 

50182,3

2293

61,3

 

V females

 

58000,6

681

52,4

 

V males

 

36647,4

495

45,8

Experimental error

M females in AA

(approximation by use of 2 libraries, see text)

1302,2

61

1,4

B.

 

Database BB

variable

F test

  

probability

 

Gender

M males versus M females

  

0,9107

  

V males versus V females

  

2,1693E-06

 

Tissue

M males versus V males

  

0,0179

  

M females versus V females

  

0,0002

 

Race

M libraries non-whites

45008,6

1053

 
  

M libraries whites

1058207,3

1921

0,0135

  1. A. After transformation of the databases to a mean expression level of 1000 per probe, the proteasome expression level appears to contribute about 50% to the variance while the experimental error contributes around 1,4%. The residual variation in expression, presumably related to epigenetic factors, is also around 50%.
  2. B. Factors contributing to the residual variation in Database BB are tissue type, gender and race.