Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements

Table 1 Results of the Fisher Omnibus test for the genomic association of pAgo genes with four classes of phage defense/stress response systems

RM	ABI	CASS	TA	Combined p-value
+	+	-	-	5.1 × 10^-7
+	+	-	+	2.9 × 10^-13
+	+	+	-	5.8 × 10^-10
+	+	+	+	4.6 × 10^-16

RM, Restriction-modification related COGs; ABI, abortive infection related COGs; CASS, CASS-associated systems; TA, toxin-antitoxin systems related COGs. The phage defense systems that were included in the target genes combination in each of the 4 analyses with the Fisher Omnibus test are shown by "+" (for instance, the first row shows the results of statistical analysis for RM and ABI systems).

ISSN: 1745-6150