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Table 3 Metal dependence of the enzyme catalytic activities.

From: On the origin of life in the Zinc world. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on Earth

Enzyme class Zn Mn Fe2+ Fe3+ Cu Co Ni Mo
Oxidoreductases 1 1 33 6 6 1 1 7
Transferases 1 5       
Hydrolases 17 4 1a 1    1  
Lyases 6 2 1 1   1   
Isomerases   2     5   
Ligases         
  1. The numbers of enzymes with particular transition metals as catalytic cofactors are from the MACiE database [179, 180], and its recently described Metal-MACiE supplement [181, 182], see text for details.
  2. a – Peptide deformylase, where the Fe atom is functionally replaceable by Co, Ni or Zn [185].