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Table 3 Metal dependence of the enzyme catalytic activities.

From: On the origin of life in the Zinc world. 2. Validation of the hypothesis on the photosynthesizing zinc sulfide edifices as cradles of life on Earth

Enzyme class

Zn

Mn

Fe2+

Fe3+

Cu

Co

Ni

Mo

Oxidoreductases

1

1

33

6

6

1

1

7

Transferases

1

5

      

Hydrolases

17

4

1a

1

  

1

 

Lyases

6

2

1

1

 

1

  

Isomerases

 

2

   

5

  

Ligases

        
  1. The numbers of enzymes with particular transition metals as catalytic cofactors are from the MACiE database [179, 180], and its recently described Metal-MACiE supplement [181, 182], see text for details.
  2. a – Peptide deformylase, where the Fe atom is functionally replaceable by Co, Ni or Zn [185].