Enzyme class | Zn | Mn | Fe2+ | Fe3+ | Cu | Co | Ni | Mo |
---|
Oxidoreductases | 1 | 1 | 33 | 6 | 6 | 1 | 1 | 7 |
Transferases | 1 | 5 | Â | Â | Â | Â | Â | Â |
Hydrolases | 17 | 4 | 1a | 1 | Â | Â | 1 | Â |
Lyases | 6 | 2 | 1 | 1 | Â | 1 | Â | Â |
Isomerases | Â | 2 | Â | Â | Â | 5 | Â | Â |
Ligases | Â | Â | Â | Â | Â | Â | Â | Â |
- The numbers of enzymes with particular transition metals as catalytic cofactors are from the MACiE database [179, 180], and its recently described Metal-MACiE supplement [181, 182], see text for details.
- a – Peptide deformylase, where the Fe atom is functionally replaceable by Co, Ni or Zn [185].